ANTIOXIDANT TREATMENTS IN THE PROPHYLAXIS OF INTESTINAL REPERFUSION DAMAGE

Abstract Introduction Intestinal ischemia-reperfusion is still a relevant clinical problem, especially in newborns and the elderly. In this piece of work, we check utility curcumin dexmedetomidine to overcome damage induced by reperfusion, both locally distant organs, using α-tocopherol as comparison. Methods female Wag/RijHsd rats, superior mesenteric artery was clamped for 1 h; then, animals were allowed 4 h reperfusion. Curcumin (200 mg/kg, oral) given 24 2 before clamping; (20 i.p.) administered ischemia, (10 or 40 s.c.; dex-10 dex-40, respectively) 15 minutes ischemia. Blood samples terminal ileum collected. Additionally, D-xylose absorption test performed evaluate intestinal absorption; 1h after administration, plasma levels quantified (mg/ml). Results All treatments reduced histological assessed with Chiu's scale (non-treated, 2.6 ± 0.75; curcumin, 1.54 0.8; dex-10, 1.47 0.7; dex-40 1.43 0.9; α-tocopherol, 1.01 0.8) improved (healthy rats 2.06 0.07; non-treated, 1.18 1.76 0.30; 2.29 0.20; 2.25 0.26; 1.66 0.21). Dexmedetomidine renal function (it creatinine urea serum). The elevation liver enzymes serum not any drugs. Conclusions three drugs proved be useful, though more efficient regarding damage, only restored normal values.